Black Jack tells Dr. White to change the course of the Sky Hospital to the North Pole while they are told that the Doctors from around the world are working to cure to the Phoenix disease. Dr. Kuma reveals that they only have 21 hours to find a cure or die before a Nuclear Missile will be fired to destroy the Virus and all those infected. Renka boards the Sky Hospital planning to kill Jack, but her father, Zen Mantoku, tries to stop her and they shoot each other. Zen Mantoku dies but Renka survives and Jack operates to save her. Jack discovers an anti-virus in her system and which will cure to the Phoenix disease, but the missile has been launched. As the Phoenix disease continues to spread in Black Jack's body, he passes out and sees Benitokage, Dr. Kiriko, Dr. Honma, and his parents, all telling him that he's done enough. He also sees Pinoko in an adult 18-year-old form who tells him that the patients are still waiting and that she will never leave his side. Dr. White successfully evades the missile detonation, flying everyone to safety. The cure is named Honma Antiserum in honor of Dr. Honma and is made free to anyone in need. Finally Jack and Pinoko return the site of his ruined house and he decides to rebuild. (Source: Wikipedia)