Orihime and Uryuu continue towards Rukia's location, but are accosted by Makizou Aramaki, a Soul Reaper of the eleventh division. Some twelfth division members arrive to help, but Mayuri, who has made them into human bombs, detonates them. Orihime uses her powers to protect Uryuu and herself from the explosions, and Mayuri expresses his wish to experiment on Orihime. Uryuu begins to fight Mayuri, but is quickly disabled by the paralyzing abilities of Mayuri's zanpakutou when his lieutenant, Nemu Kurotsuchi, uses her body to hold down Uryuu. Mayuri then reveals that he has experimented on many other Quincy, including Uryuu's grandfather, Souken Ishida, and was responsible for his death. (Source: Wikipedia) Soul Society: The Rescue arc: (2/22)