Gintama° - episode 42 - 26 Jan, 2016

Overall episode #307 Shogun Assassination Arc Part Eight: As the bloodbath comes to the end, Nobunobu becomes the new shogun of Edo as Shigeshige and Soyo seek refuge outside as they bid farewell to the Yorozuya, the Shinsengumi and the Oniwaban. While seeking refuge, Shigeshige gets poisoned by one of his guests and seeks medical attention, but as he gets closer to death, he feels relieved that he can now finally rest in peace. (Source: Wikipedia)